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Overwhelm from a biological perspective is not so desperate as it is from a psychological perspective.
Overwhelm is a normal event in the life of any organism in the living world, and as such there are well developed metabolic, physiological adaptive pathways that detect a state of overwhelm, that come into effect when overwhelm occurs, and that detect when the overwhelming conditions have ended - and that re-adapt. Overwhelm in biological terms is a temporary, transitory state.
What should first be realised is that exactly the same physiological resources and mechanisms are used regardless of the stressor that might potentially cause overwhelm - whether that is emotional/social, threat, thermal (temperature too high or too low), chemical/toxicity, infection, immunological, or anything else.
Overwhelm responses were mapped for very simple organisms by Russian biologist AA Ukhtomsky, and his findings apply to life at all scales (see Figure below).
There are essentially three kinds of biological overwhelm:
Overwhelm begins with Plan A+, which them collapses to Plan B+, and then most of the body reverts to the window of normal adaptation, leaving this pair of survival adaptations behind. All overwhelm imprints are of this form - there is a high-energy part and a low-energy part. Often people are aware of neither - they just have "personality quirks" and intolerances of people or situations. Some are aware of just one. But many people they are aware of both - some numbness, some hyperarousal.
These imprints remain active, trying to save your life, sometimes for decades, until the body-mind receives information in a form it recognises that the situation has ended. You could accurately think of these as being fragments of yourself, stuck in a time-warp, living a never-ending overwhelming moment.